CZ | EN
UCT Prague logo
UCT Repository Prague DOCTORAL THESIS

New human insulin analogues for specific interactions with insulin receptor isoforms and the IGF-1 receptor

Nové analogy lidského insulinu pro specifickou interakci s izoformami receptoru insulinu a s receptorem pro IGF-1

Circular user icon
Ing. Terezie Páníková, Ph.D.
UCT Repository Prague DOCTORAL THESIS

New human insulin analogues for specific interactions with insulin receptor isoforms and the IGF-1 receptor

Nové analogy lidského insulinu pro specifickou interakci s izoformami receptoru insulinu a s receptorem pro IGF-1

Circular user icon
Ing. Terezie Páníková, Ph.D.

ANOTACE

Insulin a insulinu podobné růstové hormony 1 a 2 (IGF-1 a IGF-2) spolu oběma isoformami receptoru insulinu (IR-A a IR-B), receptorem pro IGF-1 (IGF-1R) a receptorem pro IGF-2 (IGF-2) tvoří komplexní systém zodpovědný za regulaci bazálního metabolismu organismu, jeho vývoje, růstu a délky života, ale i ve vývoji diabetu či rakoviny. Hormony sdílí podobné primární sekvence a 3D struktury a váží se na receptory s různými afinitami. Insulin interaguje primárně s IR-A a IR-B. Oba růstové hormony signalizují hlavně přes IGF-1R či IGF-2R, ale v menší míře i přes IR-A. Cílem této práce bude lépe pochopit, které strukturní determinanty v molekulách hormonů rozhodují o specifitě pro receptory a dále navrhnout takové analogy hormonů, které se budou vyznačovat bud‘ větší nebo naopak menší selektivitou vůči recepto…

ANNOTATION

Insulin and insulin-like growth factors 1 and 2(IGF-1 and IGF-2) altogether with both isoforms of insulin receptor (IR-A and IR-B), receptor for IGF-1 (IGF-1R) and receptor for IGF-2 (IGF-2R) form a complex system responsible for a regulation of basal metabolism of the organism, growth, development, life-span but also diabetes and cancer. Hormones have similar primary sequences, 3D structures and bind cognate receptors with different affinities. Insulin interacts primarily with IR-A and IR-B. Both growth factors induce signaling through IGF-1R or IGF-2R but also partly via IR-A. The aim of this work is to better understand, which structural determinants in hormones are important for receptor specificity and to propose and design new hormone analogues, which will be more or less receptor specific than n…

FULL TEXT
Abstract in Czech
Abstract in English
Advisor
RNDr. Jiří Jiráček, CSc.
Thesis type
Doctoral thesis
Institution
University of Chemistry and Technology, Prague
Faculty
Faculty of Food and Biochemical Technology
Department
Department of Biochemistry and Microbiology
Study programme
Biochemistry
Specialization / field
Chemistry
MŠMT code
1406V002
Language
English
Access rights
open access
SIS ID
29347
Date available
Jun 7, 2023
Date modified
Jun 7, 2023
Date defended
May 24, 2023DEFENDED